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Background: Alzheimer's disease AD is a devastating neurodegeneration with a characteristic deficit in cholinergic neurotransmission. Treatment with acetylcholinesterase AChE inhibitors aims to reverse this deficit and does free xxx indianapolis chat the decline in cognition in some AD patients, although response is variable.
Objective: To examine whether sequence variation in the gene encoding choline acetyltransferase CHATwhich encodes the major catalytic enzyme of the cholinergic pathway, predicts response to AChE inhibitors. Methods: Alzheimer's disease patients were treated with cholinesterase inhibitors and the effect of treatment on cognition was adult chat clarksville using the Mini Mental State Examination MMSE.
Abstract Background: Alzheimer's disease AD is a devastating neurodegeneration with a characteristic deficit in cholinergic neurotransmission. Publication types Research Support, Non-U.